2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. eIF4EBP3 Antibody (YA1080)(PBS only)

eIF4EBP3 Antibody (YA1080)(PBS only)

製品番号: HY-P81335A
User Guide for Antibodies Technical Support

eIF4EBP3 Antibody (YA1080) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to eIF4EBP3.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

eIF4EBP3 Antibody (YA1080) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to eIF4EBP3.
Host

Mouse
分子量
Predicted band size: 11 kDa;
Observed band size: 11 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human EIF4EBP3.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
純度 Affinity Purified Conjugation Non-conjugated
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010)
Subcellular Localization：Cytoplasm; Nucleus
Expression：
Tissue_specificity:The gene is expressed at the highest levels in skeletal muscle, heart, kidneys, and pancreas, but at very low levels in the brain and thymus.
Subunit：Interacts with EIF4E (PubMed:9593750). Interacts with RPA2 (in unphosphorylated form via N-terminus); the interaction enhances EIF4EBP3-mediated inhibition of EIF4E-mediated mRNA nuclear export (PubMed:22684010)
Research Field

Epigenetics and Nuclear Signaling
Synonyms
4EBP3; 4E-BP3
ドキュメンテーション
User Guide for Antibodies (1077 KB)

eIF4EBP3 Antibody (YA1080)(PBS only) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
eIF4EBP3 Antibody (YA1080)(PBS only)
製品番号:
HY-P81335A
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