FAIM3 Antibody (YA8367)
(Synonyms: FAIM3; TOSO)FAIM3 Antibody (YA8367) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FAIM3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
FAIM3 Antibody (YA8367) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FAIM3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 43 kDa
Full length human recombinant protein of human FAIM3 produced in HEK293 Cells.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FAIM3 is a High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cell membrane,Early endosome membrane,Golgi apparatus, trans-Golgi network membrane,Lysosome membrane,Secreted
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Expression
Tissue_Specificity: Expressed by CD19-positive B cells and CD4-positive and CD8-positive T cell populations in primary and secondary lymphoid tissues (at protein level). Among B cell subsets, detected in a subset of bone marrow pro- and pre-B cells, in most follicular and memory B cells and in a small subset of germinal center B cells (at protein level). Expressed at lower levels in CD56-positive NK cells (at protein level) (PubMed:19858324, PubMed:21908732, PubMed:22675200, PubMed:30840890). Expressed in lymph nodes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland
Induction: Regulated by circulating IgM levels and immune cell activation signaling. Down-regulated in activated T cells, effector memory and central memory T cells, as well as in activated NK cells (PubMed:19858324, PubMed:22675200, PubMed:30840890, PubMed:9586636). Transcriptionally down-regulated upon TLR9 signaling (PubMed:21908732). Down-regulated in response to IL7 and IL15 (PubMed:30840890). Down-regulated in old age (PubMed:30840890) -
Isoforms & Post-Translational Modification
O60667 has three isomers: O60667-1: 43146 Da (predicted); O60667-2: 31029 Da (predicted); O60667-3: 33828 Da (predicted).
Phosphorylated on both Tyr and Ser residues丨O-glycosylated -
Subunit
Interacts (via Ig-like domain) with IGHM (via CH4/Cmu4 domain), both secreted and membrane-bound IgM; the interaction is glycan-independent and multivalent theoretically involving up to eight binding sites for the IgM pentamer
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SwissProt ID
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Synonyms
FAIM3; TOSO
Documentation
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