FES Antibody (YA2820)
(Synonyms: FPS)FES Antibody (YA2820) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FES.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
FES Antibody (YA2820) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FES.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 93 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 93 kDa
A synthetic peptide of human FES
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FES is a Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28
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Subcellular Localization
Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasmic vesicle; Golgi apparatus; Cell junction, focal adhesion
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Expression
Tissue_specificity:Widely expressed. Detected in adult colonic epithelial cells (protein level) (PubMed:16455651, PubMed:19051325) . Expressed in melanocytes (protein level) (PubMed:28463229) . -
Isoforms & Post-Translational Modification
P07332 has 4 isomers: P07332-1: 93497 Da (predicted); P07332-2: 78633 Da (predicted); P07332-3: 86663 Da (predicted); P07332-4: 85466 Da (predicted).
Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK -
Subunit
Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules
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SwissProt ID
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Synonyms
FPS
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Research Field
Signal Transduction
Documentation
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