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Glut-1 Antibody (YA7379)

(Synonyms: GLUT1, SLC2A1, HepG2 glucose transporter, GLUT-1)
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Based on 1 publication(s) in Google Scholar

Glut-1 Antibody (YA7379) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Glut-1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, ELISA

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • Glut-1 Antibody (YA7379) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:1000-1:5000 1:10000-1:50000 1:200-1:1000 1:5000-1:20000

Product Details

Description

Glut-1 Antibody (YA7379) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Glut-1.

  • Host Rabbit
  • Clonality Monoclonal,Recombinant
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 50-300 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 54 kDa
Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GLUT1 (SLC2A1) provides basal glucose uptake and supports cellular glucose transport across physiological and pathological contexts[1]. Mechanistically, GLUT1 belongs to the sugar porter family, where glucose transport depends on conserved substrate coordination and conformational regulation[2]. In disease models, impaired GLUT1 function causes Glut1 deficiency syndrome, a brain energy failure syndrome driven by reduced glucose transport across brain tissue barriers[3][4]. Compared with GLUT3, GLUT1 shares a conserved substrate-binding site but differs in transport affinity, making isoform distinction essential for transporter-specific experimental design[2]. GLUT1 and GLUT3 also transport dehydroascorbic acid, whereas GLUT2, GLUT5, and SGLT1 do not transport DHA in the tested oocyte system[5]. For experimental applications, WZB117 inhibits GLUT1-mediated sugar transport and downregulates glycolysis, supporting its use in glucose uptake and cancer metabolism studies[6][7].

  • Subcellular Localization

    Cell membrane,Melanosome,Photoreceptor inner segment

  • Expression


    Tissue_Specificity: Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues

  • Isoforms & Post-Translational Modification

    P11166: 492 amino acids, molecular weight 54084 Da.

  • Subunit

    Interacts with GIPC (via PDZ domain) (By similarity)

  • SwissProt ID

    P11166

  • Synonyms

    GLUT1, SLC2A1, HepG2 glucose transporter, GLUT-1

References

[1]. Pragallapati S, et al. Glucose transporter 1 in health and disease. J Oral Maxillofac Pathol. 2019 Sep-Dec;23(3):443-449. [Content Brief]

[2]. Custódio TF, et al. Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family. Life Sci Alliance. 2021 Feb 3;4(4):e202000858. [Content Brief]

[3]. Klepper J, et al. Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group. Epilepsia Open. 2020 Aug 13;5(3):354-365. [Content Brief]

[4]. Tang M, et al. Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein. Nat Commun. 2017 Jan 20;8:14152. [Content Brief]

[5]. Rumsey SC, et al. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9. [Content Brief]

[6]. Liu Y, et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther. 2012 Aug;11(8):1672-82. [Content Brief]

[7]. Ojelabi OA, et al. WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site. J Biol Chem. 2016 Dec 23;291(52):26762-26772. [Content Brief]

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Glut-1 Antibody (YA7379) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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