HIF Prolyl Hydroxylases Antibody (YA2975)
(Synonyms: PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM)HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:20 |
Product Details
HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 43 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
A synthetic peptide of human HIF Prolyl Hydroxylases
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HIF Prolyl Hydroxylases catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex
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Subcellular Localization
Endoplasmic reticulum membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts
Induction:By hypoxia in many cultured cell lines -
Isoforms & Post-Translational Modification
Q9NXG6 has 3 isomers: Q9NXG6-1: 56661 Da (predicted); Q9NXG6-2: 47211 Da (predicted); Q9NXG6-3: 63112 Da (predicted).
Glycosylated -
Subunit
Homodimer
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SwissProt ID
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Synonyms
PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM
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Research Field
Cardiovascular
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