Copy Link Print Information

HMGCL Antibody (YA3024)(PBS only)

(Synonyms: 3-hydroxymethyl-3-methylglutaryl-CoA lyase; HL)

HMGCL Antibody (YA3024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGCL.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • HMGCL Antibody (YA3024)(PBS only) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

HMGCL Antibody (YA3024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGCL.

  • Host Rabbit
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 34 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 34 kDa
Immunogen

A synthetic peptide of human HMGCL

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    HMGCL is a Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism

  • Subcellular Localization

    Mitochondrion matrix; Peroxisome

  • Expression


    Tissue_specificity:Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%) , skeletal muscle (22%) , and brain (14%)

  • Isoforms & Post-Translational Modification

    P35914 has 3 isomers: P35914-1: 34360 Da (predicted); P35914-2: 26910 Da (predicted); P35914-3: 20222 Da (predicted).

  • Subunit

    Homodimer; disulfide-linked. Can also form homotetramers

  • SwissProt ID

    P35914

  • Gene ID
    3155 [NCBI]
  • Synonyms

    3-hydroxymethyl-3-methylglutaryl-CoA lyase; HL

  • Research Field

    Signal Transduction

HMGCL Antibody (YA3024)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • HMGCL Antibody (YA3024)(PBS only) Product Image
    1/16
  • HMGCL Antibody (YA3024)(PBS only) Product Image