Human IgE Antibody (YA6863)
Human IgE Antibody (YA6863) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Human IgE.
-
Host:
Mouse
-
Application:
WB, IHC-P, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in 0.01M Phosphate Buffered Saline, pH7.2, 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|
| Dilution Ratio | 1:5000-20000 | 1/500-1/1000 | 1/5000-1/20000 |
Product Details
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 0.01M Phosphate Buffered Saline, pH7.2, 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Human IgE is an Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen[1][2][3].
-
Subcellular Localization
Secreted,Cell membrane
-
Isoforms & Post-Translational Modification
P0DOX4: 547 amino acids, molecular weight 60323 Da.
-
Subunit
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked
Documentation
[1]. Schroeder HW Jr, et al. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S41-52. [Content Brief]
[2]. McHeyzer-Williams M, et al. Molecular programming of B cell memory. Nat Rev Immunol. 2011 Dec 9;12(1):24-34. [Content Brief]
[3]. Teng G, et al. Immunoglobulin somatic hypermutation. Annu Rev Genet. 2007;41:107-20. [Content Brief]
Powered by Bioz
