MAFB Antibody (YA7923)
(Synonyms: DURS3; KRML; MCTO)MAFB Antibody (YA7923) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MAFB.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100 |
Product Details
MAFB Antibody (YA7923) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MAFB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 35.6 kDa
Human recombinant protein fragment corresponding to amino acids 32-320 of human MAFB produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAFB acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q9Y5Q3: 323 amino acids, molecular weight 35792 Da.
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Subunit
Homodimer or heterodimer with other bHLH-Zip transcription factors
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SwissProt ID
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Synonyms
DURS3; KRML; MCTO
Documentation
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