MAFB Antibody (YA7923)

Cat. No.: HY-P88239: Data Sheet User Guide for Antibodies
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MAFB Antibody (YA7923) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MAFB.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MAFB Antibody (YA7923) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MAFB.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 35.6 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9Y5Q3

Immunogen

Human recombinant protein fragment corresponding to amino acids 32-320 of human MAFB produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity)

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Ubiquitous

Isoforms & Post-Translational Modification：Q9Y5Q3: 323 amino acids, molecular weight 35792 Da.

Subunit：Homodimer or heterodimer with other bHLH-Zip transcription factors

Synonyms

DURS3; KRML; MCTO

Documentation

User Guide for Antibodies (1077 KB)