MAP3K8 Antibody (YA8246)
(Synonyms: AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2)MAP3K8 Antibody (YA8246) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP3K8.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
MAP3K8 Antibody (YA8246) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP3K8.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 52.7 kDa
Human recombinant protein fragment corresponding to amino acids 277-461 of human MAP3K8 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAP3K8 is required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expressed in several normal tissues and human tumor-derived cell lines
Induction: Up-regulated by IL12 in T-lymphocytes. Up-regulated in subcutaneous adipose tissue of obese individuals -
Isoforms & Post-Translational Modification
P41279 has two isomers: P41279-1: 52925 Da (predicted); P41279-2: 49620 Da (predicted).
Autophosphorylated (PubMed:1833717, PubMed:8226782) -
Subunit
Forms a ternary complex with NFKB1/p105 and TNIP2
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SwissProt ID
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Synonyms
AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Documentation
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