MVK Antibody
(Synonyms: MK, LRBP, MVLK, POROK3)MVK Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MVK.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-100 |
Product Details
MVK Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MVK.
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Host Rabbit
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Clonality polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa;
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa
Fusion protein of human MVK
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MVK catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis[1][2][3][4].
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Subcellular Localization
Cytoplasm; Peroxisome
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Isoforms & Post-Translational Modification
MVK has an amino acid length of 396, molecular weight is 42451 Da.MVK 的氨基酸个数为 396 个，分子量为 42451 Da。
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Subunit
Homodimer
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SwissProt ID
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Synonyms
MK, LRBP, MVLK, POROK3
Documentation
[1]. Cho YK, et al. Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease. J Biol Chem. 2001 Apr 20;276(16):12573-8. [Content Brief]
[2]. Fu Z, et al. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24. [Content Brief]
[3]. Potter D, et al. Identification of catalytic residues in human mevalonate kinase. J Biol Chem. 1997 Oct 10;272(41):25449-54. [Content Brief]
[4]. Hinson DD, et al. Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23. [Content Brief]
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