MYO18A Antibody (YA8839)(PBS only)

Cat. No.: HY-P89155A: Data Sheet User Guide for Antibodies
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MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q92614

Immunogen

Human recombinant protein fragment corresponding to amino acids 600-1000 of human MYO18A produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:800-1500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939)

Subcellular Localization：Golgi apparatus,Golgi apparatus, trans-Golgi network,Golgi outpost,Cytoplasm, cytoskeleton, microtubule organizing center,Endoplasmic reticulum-Golgi intermediate compartment,Cytoplasm, cytoskeleton,Cytoplasm,Cell surface

Isoforms & Post-Translational Modification：Q92614 has 6 isomers: Q92614-1: 233115 Da (predicted); Q92614-2: 196438 Da (predicted); Q92614-3: 226690 Da (predicted); Q92614-4: 231240 Da (predicted); Q92614-5: 180495 Da (predicted); O95411-1: 12414 Da (predicted).

Subunit：Homodimer

Synonyms

MAJN; MYSPDZ; SP-R210; SPR210

Documentation

User Guide for Antibodies (1077 KB)