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MYO18A Antibody (YA8839)(PBS only)

(Synonyms: MAJN; MYSPDZ; SP-R210; SPR210)

MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • MYO18A Antibody (YA8839)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:800-1500

Product Details

Description

MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Human recombinant protein fragment corresponding to amino acids 600-1000 of human MYO18A produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity[1][2][3][4][5][6][7].

  • Subcellular Localization

    Golgi apparatus,Golgi apparatus, trans-Golgi network,Golgi outpost,Cytoplasm, cytoskeleton, microtubule organizing center,Endoplasmic reticulum-Golgi intermediate compartment,Cytoplasm, cytoskeleton,Cytoplasm,Cell surface

  • Isoforms & Post-Translational Modification

    Q92614 has 6 isomers: Q92614-1: 233115 Da (predicted); Q92614-2: 196438 Da (predicted); Q92614-3: 226690 Da (predicted); Q92614-4: 231240 Da (predicted); Q92614-5: 180495 Da (predicted); O95411-1: 12414 Da (predicted).

  • Subunit

    Homodimer

  • SwissProt ID

    Q92614

  • Synonyms

    MAJN; MYSPDZ; SP-R210; SPR210

MYO18A Antibody (YA8839)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • MYO18A Antibody (YA8839)(PBS only) Product Image