MYO18A Antibody (YA8839)
(Synonyms: MAJN; MYSPDZ; SP-R210; SPR210)MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:800-1500 |
Product Details
MYO18A Antibody (YA8839) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MYO18A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 600-1000 of human MYO18A produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity[1][2][3][4][5][6][7].
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Subcellular Localization
Golgi apparatus,Golgi apparatus, trans-Golgi network,Golgi outpost,Cytoplasm, cytoskeleton, microtubule organizing center,Endoplasmic reticulum-Golgi intermediate compartment,Cytoplasm, cytoskeleton,Cytoplasm,Cell surface
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Isoforms & Post-Translational Modification
Q92614 has 6 isomers: Q92614-1: 233115 Da (predicted); Q92614-2: 196438 Da (predicted); Q92614-3: 226690 Da (predicted); Q92614-4: 231240 Da (predicted); Q92614-5: 180495 Da (predicted); O95411-1: 12414 Da (predicted).
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Subunit
Homodimer
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SwissProt ID
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Synonyms
MAJN; MYSPDZ; SP-R210; SPR210
Documentation
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