NAIP Antibody (YA2792) (PBS only)
(Synonyms: BIRC1; Birc1a; NAIP; Naip1; NLRB1; psiNAIP)NAIP Antibody (YA2792) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NAIP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4).
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NAIP Antibody (YA2792) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NAIP.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 160 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 160 kDa
A synthesized peptide derived from human NAIP aa1-28.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4).
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NAIP is an Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
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Expression
Tissue_Specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord. -
Isoforms & Post-Translational Modification
NAIP has 2 isoforms, Q13075-1: amino acid length is 1403, molecular weight is 159582 Da (predicted); Q13075-2: amino acid length is 1241, molecular weight is 141329 Da (predicted).NAIP 存在 2 个异构体，Q13075-1：氨基酸个数为 1403 个，分子量为 159582 Da (预测)；Q13075-2：氨基酸个数为 1241 个，分子量为 141329 Da (预测)。
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Subunit
Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains).
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SwissProt ID
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Synonyms
BIRC1; Birc1a; NAIP; Naip1; NLRB1; psiNAIP
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Research Field
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Documentation
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