Nav1.6 Antibody (YA10106)
(Synonyms: MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6)Nav1.6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nav1.6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:2000-5000 | 1:400-800 | 1-2μg/sample |
Product Details
Nav1.6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nav1.6.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityMouse, Rat
Recombinant protein of human Nav1.6.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nav1.6 is a Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cell membrane; Cell projection, axon
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Expression
Tissue_Specificity: Expressed in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level).
Induction: Up-regulated in the hippocampus after epilepsy. -
Isoforms & Post-Translational Modification
Nav1.May be ubiquitinated by NEDD4L; which would promote its endocytosis
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Subunit
The voltage-sensitive sodium channel consists of an ion-conducting pore-forming alpha subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B) subunits.
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SwissProt ID
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Synonyms
MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6
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