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NgR3 Antibody (YA3105)

(Synonyms: NgR3; NGRH2)
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NgR3 Antibody (YA3105) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NgR3.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • NgR3 Antibody (YA3105) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-1:5000 1:50-1:100 1:00-1:500

Product Details

Description

NgR3 Antibody (YA3105) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NgR3.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 49 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 49 kDa
Species Reactivity Database
Immunogen

A synthetic peptide of human NgR3

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NgR3 is a cell surface receptor. It plays a functionally redundant role in regulating axonal regeneration during postnatal brain development and adult central nervous system development. NgR3 contributes to normal axonal migration across the brain midline and the normal formation of the corpus callosum. NgR3 protects motor neurons from apoptosis; this anti-apoptotic effect may be mediated by myelin-associated glycoprotein (MAG). NgR3 limits the number of dendritic spines and synapses during brain development. NgR3 mediates Rho activation and downstream actin cytoskeleton remodeling.

  • Subcellular Localization

    Cell membrane; Lipid-anchor, GPI-anchor; Membrane raft; Perikaryon; Cell projection

  • Expression


    Tissue_specificity:Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen

  • Subunit

    Identified in a complex that contains RTN4R, RTN4RL1 and NGFR; the interaction depends on the presence of chondroitin sulfate proteoglycans. Does not interact with MAG, OMG and RTN4

  • SwissProt ID

    Q86UN2

  • Gene ID
    146760 [NCBI]
  • Synonyms

    NgR3; NGRH2

  • Research Field

    Neuroscience

NgR3 Antibody (YA3105) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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