RTN4RL1 - reticulon 4 receptor like 1 Gene

Also Known as NgR3; NGRH2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146760

About RTN4RL1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,934,677-2,025,334 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 22 paralogues. Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues.

Summary

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RTN4RL1 Products (1)

mRNA Protein Name
NM_178568.4 NP_848663.1 reticulon-4 receptor-like 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
12694398 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
20463223 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12694398 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTN4RL1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (101 - 161)

LRR_8

LRR_8: Leucine rich repeat (198 - 255)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

reticulon-4 receptor-like 1

  • Nogo-66 receptor homolog 2

RTN4RL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RTN4RL1 Q86UN2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
RTN4RL1 Q86UN2 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
RTN4RL1 Q86UN2 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
RTN4RL1 Q86UN2 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
RTN4RL1 Q86UN2 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
RTN4RL1 Q86UN2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
RTN4RL1 Q86UN2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
RTN4RL1 Q86UN2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
RTN4RL1 Q86UN2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
RTN4RL1 Q86UN2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RTN4RL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71159 RTN4RL1/NgR3 Protein, Human (HEK293, His) Q86UN2 (C25-A419) ≥ 95%, as determined by reducing SDS-PAGE.

RTN4RL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83360 NgR3 Antibody (YA3105) WB, ICC/IF, FC Human, Mouse, Rat
HY-P83360A NgR3 Antibody (YA3105)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12335 RTN4RL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20640 Rtn4rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27150 Rtn4rl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RTN4RL1 VGNC VGNC:45797
Felis catus RTN4RL1 VGNC VGNC:64813
Bos taurus RTN4RL1 VGNC VGNC:34207
Rattus norvegicus RTN4RL1 RGD RGD:727812
Mus musculus RTN4RL1 MGD MGI:2661375
Macaca mulatta RTN4RL1 VGNC VGNC:104647
Others RTN4RL1 NCBI