NLRX1 Antibody (YA7946)(PBS only)

Cat. No.: HY-P88262A: Data Sheet User Guide for Antibodies
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NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q86UT6

Immunogen

Human recombinant protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)

Subcellular Localization：Mitochondrion outer membrane

Expression：
Tissue_Specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level)

Isoforms & Post-Translational Modification：Q86UT6 has two isomers: Q86UT6-1: 107616 Da (predicted); Q86UT6-2: 101876 Da (predicted).

Subunit：Homohexamer (PubMed:22386589)

Synonyms

CLR11.3; DLNB26; NOD5; NOD9; NOD26

Documentation

User Guide for Antibodies (1077 KB)