Nogo Receptor Antibody (YA2405)
(Synonyms: NgR; Nogo 66 receptor; Nogo receptor; Nogor; Reticulon 4 receptor; Rtn4r)Nogo Receptor Antibody (YA2405) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nogo Receptor.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50 |
Product Details
Nogo Receptor Antibody (YA2405) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nogo Receptor.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 66 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
A synthesized peptide derived from human Nogo Receptor aa350-400/473.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nogo Receptor receptor for RTN4, OMG and MAG. Functions as a receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as a receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development[1][2][3][4][5][6][7][8][9][10].
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Membrane raft; Cell projection, dendrite; Cell projection, axon; Perikaryon
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Expression
Tissue_specificity:Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter) -
Subunit
Homodimer (PubMed:18411262). Interacts with MAG (PubMed:12089450, PubMed:12839991, PubMed:18411262, PubMed:19052207). Interacts with RTN4 (PubMed:12839991, PubMed:19052207).
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SwissProt ID
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Synonyms
NgR; Nogo 66 receptor; Nogo receptor; Nogor; Reticulon 4 receptor; Rtn4r
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Research Field
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Documentation
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