NR0B1/DAX1 Antibody (YA1205)
(Synonyms: AHC; Nuclear receptor DAX-1; HHG; AHCH; DAX1; DAX-1; NROB1)NR0B1/DAX1 Antibody (YA1205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NR0B1/DAX1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.149.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
NR0B1/DAX1 Antibody (YA1205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NR0B1/DAX1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52 kDa
A synthesized peptide derived from human DAX1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.149.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NR0B1/DAX1 is a Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency[1][2][3][4].
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Subcellular Localization
Nucleus; Cytoplasm
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Isoforms & Post-Translational Modification
P51843 has 2 isomers: P51843-1: 51718 Da (predicted); P51843-2: 43590 Da (predicted).
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Subunit
Homodimer (PubMed:16709599). Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (PubMed:10713076, PubMed:12482977, PubMed:16709599, PubMed:26416531, PubMed:32433991). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity)
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SwissProt ID
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Synonyms
AHC; Nuclear receptor DAX-1; HHG; AHCH; DAX1; DAX-1; NROB1
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Research Field
Neuroscience
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