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NUDT12 Antibody (YA8712)(PBS only)

(Synonyms: DKFZp761I172)

NUDT12 Antibody (YA8712) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUDT12.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NUDT12 Antibody (YA8712)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

NUDT12 Antibody (YA8712) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUDT12.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 51.9 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-251 of human NUDT12 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NUDT12 is a mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver[1][2][3].

  • Subcellular Localization

    Cytoplasm,Peroxisome,Cytoplasmic granule

  • Isoforms & Post-Translational Modification

    Q9BQG2 has two isomers: Q9BQG2-1: 52076 Da (predicted); Q9BQG2-2: 50052 Da (predicted).

  • Subunit

    Homodimer (PubMed:31875550)

  • SwissProt ID

    Q9BQG2

  • Synonyms

    DKFZp761I172

NUDT12 Antibody (YA8712)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NUDT12 Antibody (YA8712)(PBS only) Product Image