NUDT12 Antibody (YA8712)
(Synonyms: DKFZp761I172)NUDT12 Antibody (YA8712) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUDT12.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
NUDT12 Antibody (YA8712) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUDT12.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 51.9 kDa
Human recombinant protein fragment corresponding to amino acids 1-251 of human NUDT12 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NUDT12 is a mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver[1][2][3].
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Subcellular Localization
Cytoplasm,Peroxisome,Cytoplasmic granule
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Isoforms & Post-Translational Modification
Q9BQG2 has two isomers: Q9BQG2-1: 52076 Da (predicted); Q9BQG2-2: 50052 Da (predicted).
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Subunit
Homodimer (PubMed:31875550)
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SwissProt ID
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Synonyms
DKFZp761I172
Documentation
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