PE-conjugated CD42b Antibody (HIP1)
(Synonyms: CD42b,CD42b-PE,HIP1)PE-conjugated CD42b Antibody (HIP1) is a Mouse-derived and PE conjugated monoclonal antibody, targeting to CD42b.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
PE
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
PE-conjugated CD42b Antibody (HIP1) is a Mouse-derived and PE conjugated monoclonal antibody, targeting to CD42b.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
PE
Unmodified
Mouse IgG1,κ
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD42b (GPIbα) is a platelet membrane glycoprotein encoded by the GP1BA gene. It is the core functional subunit of the GPIb-IX-V complex responsible for directly recognizing and binding vWF. CD42b is mainly expressed in platelets and megakaryocytes, mediating the initial adhesion of platelets to the damaged vessel wall after vascular injury. It is a key initiation molecule for normal hemostasis and thrombosis. CD42b is not only an important pathogenic protein related to Bernard-Soulier syndrome, but also a classic biomarker in platelet function testing, AML-M7 immunophenotyping, and megakaryocyte differentiation research.
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Subunit
Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (PubMed:17008541, PubMed:2070794). Interacts with FLNB (PubMed:9651345). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450)
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Synonyms
CD42b,CD42b-PE,HIP1
Documentation
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