country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P82659A

Phospho-c-Myb (Ser11) Antibody (YA2404)(PBS only)

Name: Phospho-c-Myb (Ser11) Antibody (YA2404)(PBS only)
Brand: MedChemExpress
SKU: HY-P82659A
Availability: PreOrder

(Synonyms: MYB; Transcriptional activator Myb; Proto-oncogene c-Myb)

Phospho-c-Myb (Ser11) Antibody (YA2404) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Myb (Ser11).

For research use only. We do not sell to patients.

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IP IP: Immunoprecipitation	ChIP ChIP: Chromatin Immunoprecipitation
Dilution Ratio	1:500-1:1000	50-1:100	1:20	1:20

Description

Phospho-c-Myb (Ser11) Antibody (YA2404) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Myb (Ser11).

Host Rabbit
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 72 kDa

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser11 of human v-Myb/c-Myb

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

c-Myb transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
Subcellular Localization

Nucleus
Expression

Induction:Negatively regulated by microRNA-155 (miR-155)
Isoforms & Post-Translational Modification

P10242 has 12 isomers: P10242-1: 72341 Da (predicted); P10242-2: 72032 Da (predicted); P10242-3: 40620 Da (predicted); P10242-4: 85475 Da (predicted); P10242-5: 46065 Da (predicted); P10242-6: 75526 Da (predicted); P10242-7: 85166 Da (predicted); P10242-8: 83626 Da (predicted); P10242-9: 68135 Da (predicted); P10242-10: 68308 Da (predicted); P10242-11: 63198 Da (predicted); P10242-12: 37507 Da (predicted).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation;SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition;Phosphorylated by NLK on multiple sites, which induces proteasomal degradation;Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels
Subunit

Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1
SwissProt ID

P10242
Gene ID

4602 [NCBI]
Synonyms

MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
Research Field

Epigenetics and Nuclear Signaling