Phospho-Yes1 (Tyr426) Antibody
(Synonyms: YES1; YES; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes)
Based on 1 Customer Validation
Phospho-Yes1 (Tyr426) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Yes1 (Tyr426).
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
Phospho-Yes1 (Tyr426) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Yes1 (Tyr426).
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityMouse, Rat Predicted Reactivity: Human,Rabbit,Chicken,Pig,Cow,Dog,Guinea Pig
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 60 kDa
KLH conjugated Synthesised phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426 : NE(p-Y)TA
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Yes1 plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles[1][2][3][4][5][6].
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Subcellular Localization
Endoplasmic reticulum membrane; Peripheral membrane protein; Lipid droplet; Cytoplasmic vesicle, autophagosome
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Expression
Tissue_specificity:Detected in blood platelets and leukocytes (at protein level) . Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain
Induction: (Microbial infection) By Dengue virus infection (at protein level) -
Isoforms & Post-Translational Modification
Q9Y679 has 2 isomers: Q9Y679-2: 45787 Da (predicted); Q9Y679-3: 41385 Da (predicted).
Monoubiquitinated and diubiquitinated;(Microbial infection) Not ubiquitinated following Dengue virus infection -
Subunit
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1 (PubMed:18711132). Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (PubMed:12042322). Interacts (via C-terminus) with ubiquitin-conjugating enzyme UBE2G2; the interaction recruits UBE2G2 to lipid droplets (PubMed:21127063, PubMed:23223569). Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; this promotes interaction of UBE2G2 with AMFR and RNF139 (PubMed:23223569). Interacts with apolipoprotein APOB (PubMed:28183703)
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SwissProt ID
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Synonyms
YES1; YES; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes
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