PICK1 Antibody (YA1632)

製品番号: HY-P81887: データシート User Guide for Antibodies
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PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 47 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NRD5

Gene ID

9463 [NCBI]

Immunogen

A synthetic peptide of human PICK1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000
IP IP: Immunoprecipitation	1:20-1:50

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function

Subcellular Localization：Cytoplasm, perinuclear region; Membrane; Peripheral membrane protein; Membrane; Lipid-anchor; Postsynaptic density; Synapse, synaptosome; Cytoplasm, cytoskeleton

Expression：
Tissue_specificity:Ubiquitous

Isoforms & Post-Translational Modification：Q9NRD5 has 2 isomers: Q9NRD5-1: 46600 Da (predicted); Q9NRD5-2: 39808 Da (predicted).
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors;Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD)

Subunit：Monomer and homodimer. Interacts with CXADR.

Database

Entrez Gene: 9463 Human

SwissProt: Q9NRD5 Human

OMIM: 605926 Human

Research Field

Neuroscience

Synonyms

PICK 1; Pick1; PRKCABP

ドキュメンテーション

User Guide for Antibodies (1077 KB)