2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. PICK1 Antibody (YA1632)

PICK1 Antibody (YA1632)

Cat. No.: HY-P81887
User Guide for Antibodies Technical Support

PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 47 kDa;
Observed band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human PICK1
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:5000
IP
IP: Immunoprecipitation
1:20-1:50
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Subcellular Localization：Cytoplasm, perinuclear region; Membrane; Peripheral membrane protein; Membrane; Lipid-anchor; Postsynaptic density; Synapse, synaptosome; Cytoplasm, cytoskeleton
Expression：
Tissue_specificity:Ubiquitous
Isoforms & Post-Translational Modification：Q9NRD5 has 2 isomers: Q9NRD5-1: 46600 Da (predicted); Q9NRD5-2: 39808 Da (predicted).
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors;Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD)
Subunit：Monomer and homodimer. Interacts with CXADR.
Database

Entrez Gene: 9463 Human

SwissProt: Q9NRD5 Human

OMIM: 605926 Human

Research Field

Neuroscience
Synonyms
PICK 1; Pick1; PRKCABP
Documentation
User Guide for Antibodies (1077 KB)

PICK1 Antibody (YA1632) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PICK1 Antibody (YA1632)
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