PPAP2A Antibody (YA8025)
(Synonyms: LLP1a; LPP1; PAP-2a; PAP2; PPAP2A)PPAP2A Antibody (YA8025) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPAP2A.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
PPAP2A Antibody (YA8025) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPAP2A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 32 kDa
Full length human recombinant protein of human PPAP2A produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPAP2A is a Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P. Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes. May also have an intracellular activity to regulate phospholipid-mediated signaling pathways[1][2][3][4][5][6][7].
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Subcellular Localization
Cell membrane,Apical cell membrane,Membrane raft,Membrane, caveola
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Expression
Tissue_Specificity: Widely expressed with highest expression found in prostate (PubMed:9305923). Found to be down-regulated in colon adenocarcinomas (PubMed:9570154)|Predominant in kidney, lung, placenta and liver|Predominant in heart and pancreas
Induction: By androgens -
Isoforms & Post-Translational Modification
O14494 has two isomers: O14494-1: 32156 Da (predicted); O14494-2: 32150 Da (predicted).
N-glycosylated (PubMed:10962286, PubMed:9305923) -
Subunit
Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (By similarity)
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SwissProt ID
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Synonyms
LLP1a; LPP1; PAP-2a; PAP2; PPAP2A
Documentation
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