PRDM16 Antibody (YA7205)
(Synonyms: Kiaa1675, Mel1, Prdm16, Histone-lysine N-methyltransferase PRDM16, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1)PRDM16 Antibody (YA7205) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to PRDM16.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS(pH 7.3), 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
PRDM16 Antibody (YA7205) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to PRDM16.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 110 kD
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 150 kDa
Recombinant protein of human PRDM16.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.3), 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PRDM16 binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions as a repressor of TGF-beta signaling |Binds DNA and functions as a transcriptional regulator. Functions as a repressor of TGF-beta signaling. May regulate granulocyte differentiation[1][2][3].
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Subcellular Localization
Nucleus,Cytoplasm
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Expression
Tissue_Specificity: Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells -
Isoforms & Post-Translational Modification
Q9HAZ2 has four isomers: Q9HAZ2-1: 140251 Da (predicted); Q9HAZ2-2: 138177 Da (predicted); Q9HAZ2-3: 140263 Da (predicted); Q9HAZ2-4: 120338 Da (predicted).
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Subunit
Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct
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SwissProt ID
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Synonyms
Kiaa1675, Mel1, Prdm16, Histone-lysine N-methyltransferase PRDM16, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1
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