RAB21 Antibody (YA7170)
(Synonyms: KIAA0118, RAB21, Ras-related protein Rab-21)RAB21 Antibody (YA7170) is a Mouse-derived and non-conjugated IgG2b, Kappa monoclonal antibody, targeting to RAB21.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
RAB21 Antibody (YA7170) is a Mouse-derived and non-conjugated IgG2b, Kappa monoclonal antibody, targeting to RAB21.
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Host Mouse
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 24kDa;
Recombinant human RAB21 between 1-225 amino acids.
Endogenous
affinity purified by Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB21 is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10[1][2][3].
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Subcellular Localization
Endoplasmic reticulum membrane,Golgi apparatus, trans-Golgi network,Golgi apparatus membrane,Early endosome membrane,Cytoplasmic vesicle membrane,Cleavage furrow,Cell projection, neuron projection
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Expression
Tissue_Specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression -
Isoforms & Post-Translational Modification
Q9UL25: 225 amino acids, molecular weight 24348 Da.
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Subunit
Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity)
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SwissProt ID
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Synonyms
KIAA0118, RAB21, Ras-related protein Rab-21
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