RBPJK Antibody (YA099)
RBPJK Antibody (YA099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RBPJK.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human
-
Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:1000-1:5000 |
Product Details
RBPJK Antibody (YA099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RBPJK.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 56 kDa
Synthetic peptide corresponding to Human RBPJK.AA range:81-184.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity)
-
Subcellular Localization
Nucleus; Cytoplasm
-
Isoforms & Post-Translational Modification
Q06330 has 7 isomers: Q06330-1: 55637 Da (predicted); Q06330-2: 47180 Da (predicted); Q06330-3: 45642 Da (predicted); Q06330-4: 54146 Da (predicted); Q06330-5: 51877 Da (predicted); Q06330-6: 54427 Da (predicted); Q06330-7: 54297 Da (predicted).
-
Subunit
Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP.
-
SwissProt ID
-
Research Field
Neuroscience
Documentation
Powered by Bioz
