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RSPO3 Antibody (YA7994)(PBS only)

(Synonyms: CRISTIN1; PWTSR; THSD2)

RSPO3 Antibody (YA7994) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSPO3.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RSPO3 Antibody (YA7994)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

RSPO3 Antibody (YA7994) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSPO3.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 30.7 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 22-272 of human RSPO3 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RSPO3 is an Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3[1][2][3][4].

  • Subcellular Localization

    Secreted

  • Expression


    Tissue_Specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444)

  • Isoforms & Post-Translational Modification

    Q9BXY4 has two isomers: Q9BXY4-1: 30929 Da (predicted); Q9BXY4-2: 33233 Da (predicted).

  • Subunit

    Interacts with the extracellular domain of FZD8 and LRP6 (By similarity)

  • SwissProt ID

    Q9BXY4

  • Synonyms

    CRISTIN1; PWTSR; THSD2

RSPO3 Antibody (YA7994)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • RSPO3 Antibody (YA7994)(PBS only) Product Image
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  • RSPO3 Antibody (YA7994)(PBS only) Product Image