SARA Antibody (YA3226)(PBS only)
(Synonyms: NSP; SARA; MADHIP; SMADIP; PPP1R173)SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:2000-1:5000 | 1:100-1:200 |
Product Details
SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.
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Host Rabbit
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 156 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 156 kDa
A synthetic peptide of human SARA
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SARA is an Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization
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Subcellular Localization
Cytoplasm; Early endosome membrane
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Expression
Tissue_specificity:Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes -
Isoforms & Post-Translational Modification
O95405 has 3 isomers: O95405-1: 156403 Da (predicted); O95405-2: 150348 Da (predicted); O95405-3: 83721 Da (predicted).
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Subunit
Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML
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SwissProt ID
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Synonyms
NSP; SARA; MADHIP; SMADIP; PPP1R173
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Research Field
Signal Transduction
Documentation
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