SARA Antibody (YA3226)(PBS only)

製品番号: HY-P83481A: データシート User Guide for Antibodies
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Technical Support

SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.

Host

Rabbit

分子量

Predicted band size: 156 kDa;

Observed band size: 156 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

O95405

Gene ID

9372 [NCBI]

Immunogen

A synthetic peptide of human SARA

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000-1:5000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

純度	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization

Subcellular Localization：Cytoplasm; Early endosome membrane

Expression：
Tissue_specificity:Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes

Isoforms & Post-Translational Modification：O95405 has 3 isomers: O95405-1: 156403 Da (predicted); O95405-2: 150348 Da (predicted); O95405-3: 83721 Da (predicted).

Subunit：Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML

Research Field

Signal Transduction

Synonyms

NSP; SARA; MADHIP; SMADIP; PPP1R173

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/cho-cell.html [Content Brief]