SEC24D Antibody (YA3229)(PBS only)

Cat. No.: HY-P83484A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

SEC24D Antibody (YA3229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SEC24D.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SEC24D Antibody (YA3229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SEC24D.

Host

Rabbit

Molecular Weight

Predicted band size: 113 kDa;

Observed band size: 113 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O94855

Gene ID

9871 [NCBI]

Immunogen

A synthetic peptide of human SEC24D

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296)

Subcellular Localization：Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side; Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytosol

Expression：
Tissue_specificity:Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver

Isoforms & Post-Translational Modification：O94855 has 2 isomers: O94855-1: 113010 Da (predicted); O94855-2: 113081 Da (predicted).

Subunit：COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046, PubMed:27551091). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with CNIH4 (PubMed:24405750). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296). Interacts with KCNA3; this interaction is reduced in the presence of KCNE4 (PubMed:27802162)

Research Field

Synonyms

CLCRP2

Documentation

User Guide for Antibodies (1077 KB)