SEC63 Antibody
(Synonyms: ERdj2; PCLD2; SEC63L; DNAJC23; PRO2507; SEC63)SEC63 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SEC63.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Conjugation:
Non-conjugated
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Antibody Dilution Buffer (for Western Blot)
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Antibody Dilution Buffer (for Immunohistochemistry, IHC)
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Antibody Dilution Buffer (for Immunostaining)
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Ponceau Staining Solution (Ready-to-use, 1×)
HY-K1109
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WB/IP Lysis Buffer
HY-K1000
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GelHP Protein Gel (Tris-Gly, 10%, 10 well)
HY-K1111
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BCA Protein Assay Kit
HY-K2002
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Ultra High Sensitivity ECL Kit
HY-K1005
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
SEC63 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SEC63.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 88 kDa
Recombinant fusion protein
Affinity purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SEC63 mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Widely expressed, with high levels in the liver. -
Isoforms & Post-Translational Modification
SEC63 has an amino acid length of 760, molecular weight is 87997 Da.SEC63 的氨基酸个数为 760 个，分子量为 87997 Da。
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Subunit
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63
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SwissProt ID
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Synonyms
ERdj2; PCLD2; SEC63L; DNAJC23; PRO2507; SEC63
Documentation
[1]. Lang S, et al. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69. [Content Brief]
[2]. Haßdenteufel S, et al. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. Cell Rep. 2018 May 1;23(5):1373-1386. [Content Brief]
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