Syntaxin 4 Antibody (YA1849)
(Synonyms: p35 2; PLACENTAL; Stx4; STX4A; Syntaxin 4; syntaxin 4A)Syntaxin 4 Antibody (YA1849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin 4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Syntaxin 4 Antibody (YA1849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin 4.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 34 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 34 kDa
Entrez Gene: 207 Human ; 11651 Mouse ; 24185 Rat
SwissProt: P31749 Human ; P31750 Mouse ; P47196 Rat
OMIM: 114480 Human
A synthesized peptide derived from human Syntaxin 4 aa100-140.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Syntaxin 4 is a Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing[1].
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Subcellular Localization
Cell membrane; Single-pass type IV membrane protein; Cell projection, neuron projection; Cell projection, stereocilium
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Expression
Tissue_specificity:Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation -
Isoforms & Post-Translational Modification
Q12846 has 2 isomers: Q12846-1: 34180 Da (predicted); Q12846-2: 33841 Da (predicted).
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Subunit
Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity). Interacts with STXBP5L (By similarity)
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SwissProt ID
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Synonyms
p35 2; PLACENTAL; Stx4; STX4A; Syntaxin 4; syntaxin 4A
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Research Field
Neuroscience
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