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TBR1 Antibody (YA3217)

(Synonyms: T box brain 1; T-brain-1; TBR 1; Tbr1; TES 56)

TBR1 Antibody (YA3217) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBR1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

TBR1 Antibody (YA3217) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBR1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 74 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 74 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human TBR1 aa2-57/682.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TBR1 transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons[1][2].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:brain

  • Isoforms & Post-Translational Modification

    Q16650 has 2 isomers: Q16650-1: 74053 Da (predicted); Q16650-2: 42332 Da (predicted).

  • Subunit

    Homodimer (PubMed:25232744). Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity (By similarity). Interacts with FOXP2 (PubMed:25232744, PubMed:30250039). Interacts with FOXP1 (PubMed:30250039). Interacts with BCL11A (PubMed:30250039)

  • SwissProt ID

    Q16650

  • Gene ID
    10716 [NCBI]
  • Synonyms

    T box brain 1; T-brain-1; TBR 1; Tbr1; TES 56

  • Research Field

    Neuroscience

References

[1]. Deriziotis P, et al. De novo TBR1 mutations in sporadic autism disrupt protein functions. Nat Commun. 2014 Sep 18;5:4954. [Content Brief]

[2]. den Hoed J, et al. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci Rep. 2018 Sep 24;8(1):14279. [Content Brief]

TBR1 Antibody (YA3217) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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