T Box Protein 3 Antibody (YA2154)(PBS only)
(Synonyms: T box 3; T-box protein 3; Tbx3; TBX3 ISO; UMS; XHL)T Box Protein 3 Antibody (YA2154) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Mouse
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
T Box Protein 3 Antibody (YA2154) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.
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Host Rabbit
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Species ReactivityMouse
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Observed Molecular WeightObserved band size: 79 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 79 kDa
A synthetic peptide of human Tbx3
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
T Box Protein 3 transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence[1][2][3].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Widely expressed -
Isoforms & Post-Translational Modification
O15119 has 4 isomers: O15119-1: 79389 Da (predicted); O15119-2: 77178 Da (predicted); O15119-3: 65604 Da (predicted); O15119-4: Da (predicted).
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Subunit
Interacts with PML (isoform PML-4)
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SwissProt ID
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Synonyms
T box 3; T-box protein 3; Tbx3; TBX3 ISO; UMS; XHL
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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