TANK Antibody (YA8173)(PBS only)

Cat. No.: HY-P88489A: Data Sheet User Guide for Antibodies
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TANK Antibody (YA8173) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TANK.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TANK Antibody (YA8173) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TANK.

Host

Mouse

Molecular Weight

Predicted band size: 47.6 kDa

Species Reactivity

Human, Rat

SwissProt ID

Q92844

Immunogen

Full length human recombinant protein of human TANK produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-1000

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Ubiquitous

Isoforms & Post-Translational Modification：Q92844 has three isomers: Q92844-1: 47816 Da (predicted); Q92844-2: 13426 Da (predicted); Q92844-3: 13626 Da (predicted).
Phosphorylated by IKBKE丨(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073)丨(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways

Subunit：Homodimer

Synonyms

I-TRAF; ITRAF; TRAF2

Documentation

User Guide for Antibodies (1077 KB)