TANK Antibody (YA8173)(PBS only)
(Synonyms: I-TRAF; ITRAF; TRAF2)TANK Antibody (YA8173) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TANK.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:500-1000 |
Product Details
TANK Antibody (YA8173) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TANK.
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Host Mouse
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Species ReactivityHuman, Rat
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Calculated Molecular Weight Predicted band size: 47.6 kDa
Full length human recombinant protein of human TANK produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TANK is an Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2[1].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q92844 has three isomers: Q92844-1: 47816 Da (predicted); Q92844-2: 13426 Da (predicted); Q92844-3: 13626 Da (predicted).
Phosphorylated by IKBKE丨(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073)丨(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways -
Subunit
Homodimer
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SwissProt ID
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Synonyms
I-TRAF; ITRAF; TRAF2
Documentation
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