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TBC1D21 Antibody (YA8548)(PBS only)

(Synonyms: MgcRabGAP)

TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TBC1D21 Antibody (YA8548)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
Dilution Ratio 1:150-500 1:100

Product Details

Description

TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 39 kDa
Immunogen

Full length human recombinant protein of human TBC1D21 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TBC1D21 acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity[1][2][3].

  • Subcellular Localization

    Cytoplasmic vesicle, secretory vesicle, acrosome,Cytoplasm, cytoskeleton

  • Expression


    Tissue_Specificity: Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain

  • Isoforms & Post-Translational Modification

    Q8IYX1 has two isomers: Q8IYX1-1: 39221 Da (predicted); Q8IYX1-2: 34961 Da (predicted).

  • Subunit

    Interacts with ACTB (By similarity)

  • SwissProt ID

    Q8IYX1

  • Synonyms

    MgcRabGAP

TBC1D21 Antibody (YA8548)(PBS only) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • TBC1D21 Antibody (YA8548)(PBS only) Product Image
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  • TBC1D21 Antibody (YA8548)(PBS only) Product Image