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TGIF1 Antibody (YA7822)(PBS only)

(Synonyms: HPE4; TGIF)

TGIF1 Antibody (YA7822) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGIF1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TGIF1 Antibody (YA7822)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

TGIF1 Antibody (YA7822) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGIF1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 29.6 kDa
Immunogen

Full length human recombinant protein of human TGIF1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TGIF1 binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    Q15583 has four isomers: Q15583-1: 43013 Da (predicted); Q15583-2: 29737 Da (predicted); Q15583-3: 31064 Da (predicted); Q15583-4: 27715 Da (predicted).

  • Subunit

    Interacts with SMAD2 (PubMed:10835638)

  • SwissProt ID

    Q15583

  • Synonyms

    HPE4; TGIF

TGIF1 Antibody (YA7822)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TGIF1 Antibody (YA7822)(PBS only) Product Image