THOP1 (Thimet Oligopeptidase) Antibody (YA8132)
(Synonyms: EP24.15; MEPD_HUMAN; MP78; TOP)THOP1 (Thimet Oligopeptidase) Antibody (YA8132) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to THOP1 (Thimet Oligopeptidase).
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 |
Product Details
THOP1 (Thimet Oligopeptidase) Antibody (YA8132) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to THOP1 (Thimet Oligopeptidase).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 78.7 kDa
Full length human recombinant protein of human THOP1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1[1][2].
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Subcellular Localization
Cytoplasm
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Isoforms & Post-Translational Modification
P52888 has two isomers: P52888-1: 78840 Da (predicted); P52888-2: 28908 Da (predicted).
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Subunit
Monomer
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SwissProt ID
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Synonyms
EP24.15; MEPD_HUMAN; MP78; TOP
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