Toll-like Receptor 7 Antibody (YA5330)
(Synonyms: PRO285; TLR 7; Tlr7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.)Toll-like Receptor 7 Antibody (YA5330) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Toll-like Receptor 7.
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Host:
Mouse
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Application:
WB
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Reactivity :
Transfected
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
Toll-like Receptor 7 Antibody (YA5330) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Toll-like Receptor 7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityTransfected
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Calculated Molecular Weight Predicted band size: 121 kDa;
Purified recombinant human Toll-like Receptor protein fragments expressed in E.coli.
Transfected
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Toll-like Receptor 7 is an Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state[1][2][3][4][5][6][7].
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Subcellular Localization
Endoplasmic reticulum membrane; Single-pass type I membrane protein; Endosome; Lysosome; Cytoplasmic vesicle, phagosome
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Expression
Tissue_specificity:It was detected in the brain, placenta, spleen, stomach, small intestine, lungs, and plasmacytoid anterior dendritic cells. It is also expressed in peripheral blood mononuclear cells (PubMed: 32706371) . -
Subunit
Homodimer (PubMed:27742543). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (PubMed:33432245). Interacts with SMPDL3B (By similarity)
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SwissProt ID
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Synonyms
PRO285; TLR 7; Tlr7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.
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