Transmembrane Protein 43 Antibody (YA2223)(PBS only)

Cat. No.: HY-P82478A: Data Sheet User Guide for Antibodies
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Transmembrane Protein 43 Antibody (YA2223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 43.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Transmembrane Protein 43 Antibody (YA2223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 43.

Host

Rabbit

Molecular Weight

Predicted band size: 45 kDa;

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

Q9BTV4

Gene ID

79188 [NCBI]

Immunogen

A synthetic peptide of human TMEM43

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020)

Subcellular Localization：Endoplasmic reticulum membrane; Nucleus inner membrane; Multi-pass membrane protein; Cell membrane

Expression：
Tissue_specificity:Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis

Subunit：Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway (PubMed:32614325). Interacts with CARD10 (PubMed:27991920). Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (PubMed:34050020)

Research Field

Tags & Cell Markers

Synonyms

LUMA; ARVC5; ARVD5; EDMD7

Documentation

User Guide for Antibodies (1077 KB)