2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Transmembrane Protein 43 Antibody (YA2223)

Transmembrane Protein 43 Antibody (YA2223)

Cat. No.: HY-P82478
User Guide for Antibodies Technical Support

Transmembrane Protein 43 Antibody (YA2223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 43.

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사이즈 가격 재고 수량
20 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   견적 받기  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

Transmembrane Protein 43 Antibody (YA2223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 43.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 45 kDa;
Observed band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human TMEM43
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020)
Subcellular Localization：Endoplasmic reticulum membrane; Nucleus inner membrane; Multi-pass membrane protein; Cell membrane
Expression：
Tissue_specificity:Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis
Subunit：Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway (PubMed:32614325). Interacts with CARD10 (PubMed:27991920). Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (PubMed:34050020)
Database

Entrez Gene: 79188 Human ; 74122 Mouse ; 362401 Rat

SwissProt: Q9BTV4 Human ; Q9DBS1 Mouse ; Q5XIP9 Rat

OMIM: 604400 Human

Research Field

Tags & Cell Markers
Synonyms
LUMA; ARVC5; ARVD5; EDMD7
각종 서류
User Guide for Antibodies (1077 KB)

Transmembrane Protein 43 Antibody (YA2223) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
Transmembrane Protein 43 Antibody (YA2223)
Cat. No.:
HY-P82478
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