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ZFAND5 Antibody (YA8188)(PBS only)

(Synonyms: ZA20D2; ZFAND5A; ZNF216)

ZFAND5 Antibody (YA8188) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND5.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ZFAND5 Antibody (YA8188)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

ZFAND5 Antibody (YA8188) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND5.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 23 kDa
Immunogen

Full length human recombinant protein of human ZFAND5 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ZFAND5 is involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation

  • Subcellular Localization

    Cytoplasm

  • Expression


    Tissue_Specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level)

  • Isoforms & Post-Translational Modification

    O76080: 213 amino acids, molecular weight 23132 Da.

  • Subunit

    Interacts with ubiquitin and polyubiquitinated proteins

  • SwissProt ID

    O76080

  • Synonyms

    ZA20D2; ZFAND5A; ZNF216

ZFAND5 Antibody (YA8188)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • ZFAND5 Antibody (YA8188)(PBS only) Product Image
    1/16
  • ZFAND5 Antibody (YA8188)(PBS only) Product Image