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Art. -Nr.: HY-156562

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5-PT

Name: 5-PT
Brand: MedChemExpress
SKU: HY-156562
Availability: PreOrder

(Synonyms: 5-Propargyltryptamide)

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Based on 1 publication(s) in Google Scholar

5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia.

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CAS. Nr.: 92085-05-7
Formel: C₁₃H₁₄N₂O
Molecular Weight:214.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

5-PT Chemical Structure

CAS. Nr.: 92085-05-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- In Vitro
Chemical Information
Publications (1)
Protokoll (1)
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

In Vitro

5-PT (100 μM; 24 h) treatment of MLE-12 alveolar epithelial cells labels 121 unique serotonylated proteins, many of which are associated with cellular processes and cell behavior regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 92085-05-7
Molecular Weight 214.26
Formel C₁₃H₁₄N₂O
SMILES

NCCC1=CNC2=C1C=C(OCC#C)C=C2
Synonyms

5-Propargyltryptamide
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086

Protokoll

All Cell Biology

EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cai P, et al. 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. iScience. 2025;28(12):114120. Published 2025 Nov 19. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
Chemical Information
Publications (1)
Protokoll
Reinheit & Dokumentation
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