Albicidin
Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1622253-00-2
- Formel: C44H38N6O12
- Molecular Weight:842.81
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Antibiotic Isoform-spezifische Produkte anzeigen
MoreAlle Topoisomerase Isoform-spezifische Produkte anzeigen
MoreAlle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
DNA Gyrase |
In Vitro
Albicidin (30-200 nM) inhibits the DNA gyrase supercoiling activity of E. coli, with an IC50 of approximately 40 nM[1].
Albicidin exhibits potent antibacterial activity against Escherichia coli (including fluoroquinolone-resistant strains), Salmonella enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus, with MIC values ranging from 0.031 to 16 μg/mL[1].
Albicidin (0-3200 nM; 30-60 min) inhibits DNA supercoiling mediated by wild-type E. coli DNA gyrase, with an IC50 of 40 nM[2].
Albicidin (0-1600 nM; 30-60 min) inhibits the DNA supercoiling activity of mitochondrial and chloroplast DNA gyrases in Arabidopsis thaliana, with an IC50 of 50 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1622253-00-2
-
Molecular Weight 842.81
-
Formel C44H38N6O12
-
SMILES
O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973. [Content Brief]
[2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Albicidin Related Classifications
HY-108988 Related Classifications
Powered by Bioz
Keywords