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Art. -Nr.: HY-187179

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CDK2-IN-62

CDK2-IN-62 is a predicted CDK2 inhibitor. CDK2-IN-62 induces apoptosis in breast cancer cells and reduces their colony-forming ability. CDK2-IN-62 can be used for the research of breast cancer, ovarian cancer and colorectal cancer.

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Formel: C₂₇H₂₁N₃O₂S
Molecular Weight:451.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK2-IN-62 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

human CDK2

Alle CDK Isoform-spezifische Produkte anzeigen :

In Vitro

CDK2-IN-62 (Compound 4e) (48 h) inhibits the viability of MCF-7, A2780cis and HT-29 cells with IC₅₀ values of 9.19, 8.21 and 18.84 μM, respectively; it shows low toxicity to normal CHO epithelial cells^[1].
CDK2-IN-62 (9.19 μM; 48 h) inhibits clonal proliferation of human breast cancer MCF-7 cells^[1].
CDK2-IN-62 (9.19 μM; 36 h) induces apoptosis in MCF-7 human breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

9.19 μM
Incubation Time:

36 h
Result:

Increased the total percentage of apoptotic MCF-7 cells (early + late apoptosis) to 53.1%, up from 4.22% in control cells; necrotic cells accounted for 18.5% of treated cells.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

9.19 μM
Incubation Time:

48 h
Result:

Significantly reduced the number of colonies formed by MCF-7 cells compared to the control group.

Chemical Information

Molecular Weight 451.54
Formel C₂₇H₂₁N₃O₂S
SMILES

N#CC1=C(N)OC(C)=C(SC2=CC=CC=C2)C31C(N(CC4=CC=CC=C4)C5=C3C=CC=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jamshidi Z, et al. Multicomponent synthesis of novel spiro-indoline-3,4'-pyran derivatives: in silico and in vitro study. Sci Rep. 2026 Jun 27.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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CDK2-IN-62

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CDK2-IN-62 Related Classifications

HY-187179 Related Classifications

Bioz

Keywords

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