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Art. -Nr.: HY-160621

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CXF-009

CXF-009 is a selective and covalent FGFR4 inhibitor, with the IC₅₀ of 48 nM. CXF-009 targeting Cys477 and Cys552 of FGFR4, and can be used for the study of hepatocellular carcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2727084-00-4
Formel: C₃₃H₃₈N₈O₅
Molecular Weight:626.71

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CXF-009 Chemical Structure

CAS. Nr.: 2727084-00-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CXF-009 is a selective and covalent FGFR4 inhibitor, with the IC₅₀ of 48 nM. CXF-009 targeting Cys477 and Cys552 of FGFR4, and can be used for the study of hepatocellular carcinoma^[1].

IC₅₀ & Target

FGFR4

48 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>5000 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1562 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1971 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	38 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	777 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
HCC1937	IC₅₀	>10 μM Compound: CXF-009	Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Hep 3B2	IC₅₀	0.9 μM Compound: CXF-009	Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Huh-7	IC₅₀	0.73 μM Compound: CXF-009	Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
MDA-MB-453	IC₅₀	0.73 μM Compound: CXF-009	Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay	[PMID: 38432058]

Chemical Information

CAS. Nr. 2727084-00-4
Molecular Weight 626.71
Formel C₃₃H₃₈N₈O₅
SMILES

O=C(NC1=C(NC2=NC=C3C(N(CCCN4CCN(CC4)C(C=C)=O)C(N(C3)C5=CC(OC)=CC(OC)=C5)=O)=N2)C=CC=C1)C=C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen X, et al. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem. 2022;5(1):36. Published 2022 Mar 17. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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