Pik3r6 - phosphoinositide-3-kinase regulatory subunit 5 Gene

Also Known as p84; p87PIKAP; p84 PIKAP; p87(PIKAP)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104709

Summary

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Pik3r6 Products (2)

mRNA Protein Name
NM_001004435.3 NP_001004435.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 2
NM_001081566.2 NP_001075035.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
IDA: Inferred from direct assay
15797027 MGI
contributes to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
IDA: Inferred from direct assay
19906996 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15797027 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19906996 MGI
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
19906996 MGI
involved in positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
12707323 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in membrane IDA
IDA: Inferred from direct assay
19906996 MGI
part of phosphatidylinositol 3-kinase complex, class IB IDA
IDA: Inferred from direct assay
15797027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphoinositide 3-kinase regulatory subunit 6

  • p84 PI3K adapter protein

  • p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein

  • phosphoinositide 3-kinase gamma adapter protein of 87 kDa

  • phosphoinositide-3-kinase, regulatory subunit 6

Pik3r6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Pik3r6 Q3U6Q4 Pik3cg Mus musculus Q9JHG7
Anti Bait CoIP
15797027
Intra
Pik3r6 Q3U6Q4 Pik3cg Mus musculus Q9JHG7
Anti Bait CoIP
23824069
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10541 PIK3R6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3r6 NCBI NCBI:146850