2. Gene
  3. Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Gene

Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PI3Kgamma; p110gamma; p120-PI3K; 5830428L06Rik

Gene ID: 30955 | Gene type: protein coding

About Pik3cg

Chromosome 12: 32,223,472-32,258,658 reverse strand.GRCm39:CM001005.3

This gene has 7 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 50 phenotypes. Biased expression in thymus adult (RPKM 8.2), spleen adult (RPKM 4.8) and 13 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cg Products(3)

mRNA Protein Name
NM_001146200.2 NP_001139672.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
NM_020272.2 NP_064668.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
NM_001146201.2 NP_001139673.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Pik3cg Protein Structure

PIK3CG_ABD

PIK3CG_ABD: pfam19710 (0 - 191)

PI3K_rbd

PI3K_rbd: smart00144 (202 - 311)

C2_PI3K_class_I_gamma

C2_PI3K_class_I_gamma: cd08399 (349 - 526)

PI3Ka_I

PI3Ka_I: cd00872 (548 - 724)

PI3Kc_IB_gamma

PI3Kc_IB_gamma: cd00894 (728 - 1094)

  • 0
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  • 600
  • 800
  • 1000
  • 1102 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PI3-kinase subunit gamma

phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma

phosphoinositide-3-kinase, catalytic, gamma polypeptide

ptdIns-3-kinase subunit gamma

ptdIns-3-kinase subunit p110-gamma

serine/threonine protein kinase PIK3CG

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10532 PIK3CG Human Pre-designed siRNA Set A / Unkown
HY-RS10533 Pik3cg Mouse Pre-designed siRNA Set A / Unkown
HY-RS10534 Pik3cg Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3cg NCBI NCBI:5294