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Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Gene

Also Known as PI3Kgamma; p110gamma; p120-PI3K; 5830428L06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 30955

About Pik3cg

Chromosome 12: 32,223,472-32,258,658 reverse strand.GRCm39:CM001005.3

This gene has 7 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 50 phenotypes. Biased expression in thymus adult (RPKM 8.2), spleen adult (RPKM 4.8) and 13 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cg Products (3)

mRNA	Protein	Name
NM_001146200.2	NP_001139672.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
NM_020272.2	NP_064668.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
NM_001146201.2	NP_001139673.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	11054537	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15797027	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	23008439	MGI
acts upstream of or within negative regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	15192701	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18558630	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	EXP EXP: Inferred from Experiment	22728827	MGI
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	18558630	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	23008439	MGI
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18558630	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15192701	MGI
acts upstream of or within regulation of calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23008439	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23008439	MGI
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18558630	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cg Protein Structure

PIK3CG_ABD

PI3K_rbd

C2_PI3K_class_I_gamma

PI3Ka_I

PI3Kc_IB_gamma

0
200
400
600
800
1000
1102 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PI3-kinase subunit gamma phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma phosphoinositide-3-kinase, catalytic, gamma polypeptide ptdIns-3-kinase subunit gamma ptdIns-3-kinase subunit p110-gamma serine/threonine protein kinase PIK3CG

Pik3cg Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pik3cg	Q9JHG7	Pik3r6	Mus musculus	Q3U6Q4	Anti Bait CoIP	21665146

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70609	PIK3CG Recombinant Human Active Lipid Kinase		/	Unkown
HY-N0859A	Schisanhenol B		/	Unkown
HY-RS10532	PIK3CG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10533	Pik3cg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10534	Pik3cg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3cg	NCBI	NCBI:5294